GSI Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Planckstraße 1, 64291 Darmstadt, Germany.
Med Phys. 2012 Apr;39(4):1716-27. doi: 10.1118/1.3691903.
Radiation therapy using high-energy charged particles is generally acknowledged as a powerful new technique in cancer treatment. However, particle therapy in oncology is still controversial, specifically because it is unclear whether the putative clinical advantages justify the high additional costs. However, particle therapy can find important applications in the management of noncancer diseases, especially in radiosurgery. Extension to other diseases and targets (both cranial and extracranial) may widen the applications of the technique and decrease the cost/benefit ratio of the accelerator facilities. Future challenges in this field include the use of different particles and energies, motion management in particle body radiotherapy and extension to new targets currently treated by catheter ablation (atrial fibrillation and renal denervation) or stereotactic radiation therapy (trigeminal neuralgia, epilepsy, and macular degeneration). Particle body radiosurgery could be a future key application of accelerator-based particle therapy facilities in 10 years from today.
高能带电粒子放射治疗通常被认为是癌症治疗的一种强大的新技术。然而，粒子疗法在肿瘤学领域仍存在争议，特别是因为目前尚不清楚所谓的临床优势是否证明了高昂的额外成本是合理的。然而，粒子疗法在非癌症疾病的治疗中可能有重要的应用，特别是在放射外科中。该技术在其他疾病和靶点（颅内外）的应用拓展可能会降低加速器设施的成本效益比。该领域未来的挑战包括使用不同的粒子和能量、在粒子体放射治疗中进行运动管理以及拓展至目前通过导管消融（心房颤动和肾去神经支配）或立体定向放射治疗（三叉神经痛、癫痫和黄斑变性）治疗的新靶点。粒子体放射外科可能是未来 10 年内基于加速器的粒子治疗设施的一个重要应用。
