Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences, Shizuoka, Japan.
Nutrition. 2012 Oct;28(10):978-83. doi: 10.1016/j.nut.2011.12.001. Epub 2012 Apr 6.
In this study, we examined the relations between the rate of eating and circulating interleukin (IL)-1β and IL-6 levels in Japanese men not being treated for metabolic diseases.
We conducted a cross-sectional study of 170 men 40 to 59 y old (mean ± standard deviation, 51.4 ± 5.7 y old) who participated in health checkups in Japan and were not being treated for metabolic diseases. We measured clinical serum parameters and plasma IL-1β and IL-6 concentrations and assessed by questionnaire lifestyle factors such as the dietary intake of food/nutrition and the rate of eating. Using multivariate linear regression analysis, we analyzed the relations between the rate of eating and IL-1β and IL-6 concentrations, clinical parameters, and lifestyle factors.
Significant Spearman correlation coefficients with the rate of eating were observed for IL-1β and IL-6 (0.250 and 0.195, respectively). The rate of eating was positively associated with IL-1β independently of IL-6, body mass index, homeostasis model assessment for insulin resistance, alcohol intake, energy intake, smoking status, and physical activity.
These results indicate that a higher rate of eating is positively and independently associated with circulating IL-1β concentrations in Japanese men not being treated for metabolic diseases.
本研究旨在探讨未接受代谢疾病治疗的日本男性进食速度与循环白细胞介素（IL）-1β和 IL-6 水平之间的关系。
我们对参加日本健康检查且未接受代谢疾病治疗的 170 名 40 至 59 岁（平均 ± 标准差，51.4 ± 5.7 岁）男性进行了横断面研究。我们测量了临床血清参数和血浆 IL-1β和 IL-6 浓度，并通过问卷调查评估了饮食摄入的食物/营养和进食速度等生活方式因素。我们使用多元线性回归分析，分析了进食速度与 IL-1β和 IL-6 浓度、临床参数和生活方式因素之间的关系。
IL-1β 和 IL-6 与进食速度呈显著的斯皮尔曼相关系数（分别为 0.250 和 0.195）。在不考虑 IL-6、体重指数、胰岛素抵抗评估的稳态模型、酒精摄入量、能量摄入量、吸烟状况和身体活动的情况下，进食速度与 IL-1β 呈正相关。
这些结果表明，在未接受代谢疾病治疗的日本男性中，较高的进食速度与循环 IL-1β 浓度呈正相关且独立相关。
