Yamazaki Junpei, Mochizuki Kazuki, Miyauchi Rie, Ichikawa Yoko, Goda Toshinao
Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences.
J Nutr Sci Vitaminol (Tokyo). 2013;59(6):526-32. doi: 10.3177/jnsv.59.526.
We previously demonstrated that the circulating concentrations of interleukin (IL)-1β, which is known to induce the development and progression of type 2 diabetes and its complications, were positively associated with γ-glutamyltransferase (γ-GTP) activity in middle-aged apparently healthy Japanese men. It was still unknown if the association between IL-1β concentrations and γ-GTP activity is within the normal range in apparently healthy Japanese women. In this study, we conducted a cross-sectional study of 824 apparently healthy women aged 40-64 y [mean±standard deviation age, 53.1±7.1 y; body mass index (BMI), 22.0±3.1 kg/m(2)] who participated in health checkups in Japan, and whose γ-GTP activity was within the normal range (<38 U/L). Associations of γ-GTP with IL-1β and other clinical or lifestyle factors were determined using analysis of variance (ANOVA) and one-way analysis of covariance (ANCOVA) followed by Tukey's multiple-range test. Multivariate logistic regression analyses (MLRA) were performed with γ-GTP activity as the dependent variable; independent variables included IL-1β plus clinical and lifestyle factors. ANOVA and ANCOVA indicated that IL-1β concentrations were positively associated with γ-GTP activity. MLRA showed that γ-GTP activity showed trends for higher IL-1β concentrations after adjusting for age, BMI, energy intake, alcohol intake, and smoking status. Together, IL-1β concentrations are positively associated with γ-GTP activity within the normal range in middle-aged apparently healthy Japanese women. Our results suggest that γ-GTP activity would be useful for assessing inflammation from the healthy state in Japanese women.
我们之前证明，已知可诱导2型糖尿病及其并发症发生和发展的白细胞介素（IL）-1β的循环浓度，与中年表面健康的日本男性的γ-谷氨酰转移酶（γ-GTP）活性呈正相关。目前仍不清楚在表面健康的日本女性中，IL-1β浓度与γ-GTP活性之间的关联是否处于正常范围内。在本研究中，我们对824名年龄在40 - 64岁[平均±标准差年龄，53.1±7.1岁；体重指数（BMI），22.0±3.1kg/m²]、参与日本健康体检且γ-GTP活性在正常范围内（<38U/L）的表面健康女性进行了一项横断面研究。使用方差分析（ANOVA）和单因素协方差分析（ANCOVA），随后进行Tukey多重范围检验，来确定γ-GTP与IL-1β以及其他临床或生活方式因素之间的关联。以γ-GTP活性作为因变量进行多因素逻辑回归分析（MLRA）；自变量包括IL-1β以及临床和生活方式因素。ANOVA和ANCOVA表明，IL-1β浓度与γ-GTP活性呈正相关。MLRA显示，在调整年龄、BMI、能量摄入、酒精摄入和吸烟状况后，γ-GTP活性随IL-1β浓度升高呈现出一定趋势。总之，在中年表面健康的日本女性中，IL-1β浓度与正常范围内的γ-GTP活性呈正相关。我们的结果表明，γ-GTP活性可能有助于评估日本女性从健康状态开始的炎症情况。
