进食速度快会导致胰岛素抵抗：日本中年男性和女性的研究结果。

Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women.

作者信息

Otsuka Rei, Tamakoshi Koji, Yatsuya Hiroshi, Wada Keiko, Matsushita Kunihiro, OuYang Pei, Hotta Yo, Takefuji Seiko, Mitsuhashi Hirotsugu, Sugiura Kaichiro, Sasaki Satoshi, Kral John G, Toyoshima Hideaki

机构信息

Department of Public Health/Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine, Aichi, Japan.

出版信息

Prev Med. 2008 Feb;46(2):154-9. doi: 10.1016/j.ypmed.2007.07.031. Epub 2007 Aug 3.

DOI:10.1016/j.ypmed.2007.07.031

PMID:17822753

Abstract

OBJECTIVE

To examine relationships between speed of eating and insulin resistance.

METHODS

Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m(2)) and 761 female (46.3 y and 21.8 kg/m(2)) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR).

RESULTS

BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p<0.001, for trend) and in women (p<0.01). Adjusting for BMI, this positive relationship appeared only in men (p=0.03).

CONCLUSIONS

Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.

摘要

目的

研究进食速度与胰岛素抵抗之间的关系。

方法

对2704名男性（平均年龄和体重指数：48.2岁和23.3kg/m²）和761名女性（46.3岁和21.8kg/m²）非糖尿病日本公务员进行横断面研究，其中75%为文职人员，25%为体力劳动者，使用一份关于生活方式因素和饮食史的两部分问卷，自我评估一个月内的分类进食速度和能量摄入。我们测量了体重指数、血糖和胰岛素浓度，并使用胰岛素抵抗稳态模型评估法（HOMA-IR）计算胰岛素抵抗。

结果

体重指数与男女进食速度均相关，且与男性每日能量摄入相关。对按分类进食速度的对数HOMA-IR进行多元回归分析，校正年龄、能量摄入和生活方式因素后，男性（趋势p<0.001）和女性（p<0.01）的HOMA-IR均随相对进食速度增加而有统计学意义地逐渐升高。校正体重指数后，这种正相关仅在男性中出现（p=0.03）。