Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
World Neurosurg. 2013 Jan;79(1):130-5. doi: 10.1016/j.wneu.2012.03.032. Epub 2012 Apr 3.
We sought to (1) describe psychological, physical, and cognitive functions in patients 10 years after intracranial aneurysm rupture and (2) identify any differences in outcome variables between age groups, gender or aneurysm locations.
A consecutive sample of patients (n=217) treated for intracranial aneurysm rupture at a neurosurgical clinic in Stockholm, Sweden, were followed-up in a cross-sectional design 10.1 years after the onset with questionnaires and telephone interviews. The outcome measures were psychological functions in terms of symptoms of anxiety or depression and physical and cognitive functions.
Compared with the reference groups, the aneurysm patients scored greater levels of anxiety and depression than normal values. Patients with aneurysm rupture in the posterior circulation scored significantly more problems with anxiety and depression. Only 2.8% of the patients scored for severe physical disability. On a group level, cognition was lower than normal population levels; 21.7% of respondents scored below the cut-off value, indicating cognitive impairments.
Ten years after aneurysm rupture the majority of patients seem to be well-functioning physically, whereas the psychological and cognitive functions are affected. A screening of the mental health of these patients in connection to radiological follow-up might be helpful to identify which patients need further referral to psychiatric treatment for anxiety and depression disorders.
我们旨在（1）描述颅内动脉瘤破裂 10 年后患者的心理、生理和认知功能，（2）确定年龄组、性别或动脉瘤位置对结局变量的任何差异。
采用瑞典斯德哥尔摩神经外科诊所的连续样本，对接受颅内动脉瘤破裂治疗的患者（n=217）进行前瞻性随访，在发病后 10.1 年时通过问卷调查和电话访谈进行横断面设计。结局指标为焦虑或抑郁症状等心理功能以及生理和认知功能。
与参考组相比，动脉瘤患者的焦虑和抑郁评分高于正常值。后循环动脉瘤破裂患者的焦虑和抑郁问题更为严重。仅有 2.8%的患者出现严重的身体残疾。从群体水平来看，认知能力低于正常人群水平；21.7%的受访者低于临界值，表明存在认知障碍。
颅内动脉瘤破裂 10 年后，大多数患者的身体功能似乎良好，而心理和认知功能受到影响。在影像学随访的同时对这些患者的心理健康进行筛查，有助于识别出需要进一步转诊到精神科治疗焦虑和抑郁障碍的患者。
