Department of Microbiology, University of Silesia, Katowice, Poland.
Arch Immunol Ther Exp (Warsz). 2012 Jun;60(3):199-209. doi: 10.1007/s00005-012-0168-z. Epub 2012 Apr 8.
Yersinia enterocolitica is a widespread member of the family of Enterobacteriaceae that contains both non-virulent and virulent isolates. Pathogenic Y. enterocolitica strains, especially belonging to serotypes O:3, O:5,27, O:8 and O:9 are etiologic agents of yersiniosis in animals and humans. Y. enterocolitica cell surface structures that play a significant role in virulence have been subject to many investigations. These include outer membrane (OM) glycolipids such as lipopolysaccharide (LPS) and enterobacterial common antigen (ECA) and several cell surface adhesion proteins present only in virulent Y. enterocolitica, i.e., Inv, YadA and Ail. While the yadA gene is located on the Yersinia virulence plasmid the Ail, Inv, LPS and ECA are chromosomally encoded. These structures ensure the correct architecture of the OM, provide adhesive properties as well as resistance to antimicrobial peptides and to host innate immune response mechanisms.
肠侵袭性大肠埃希菌是肠杆菌科的一个广泛存在的成员，其中包含非致病性和致病性分离株。致病性肠侵袭性大肠埃希菌菌株，特别是血清型 O:3、O:5、27、O:8 和 O:9，是动物和人类耶尔森菌病的病原体。在许多研究中，肠侵袭性大肠埃希菌细胞表面结构在毒力中起着重要作用。这些结构包括外膜（OM）糖脂，如脂多糖（LPS）和肠杆菌共同抗原（ECA），以及仅存在于致病性肠侵袭性大肠埃希菌中的几种细胞表面粘附蛋白，即 Inv、YadA 和 Ail。虽然 yadA 基因位于耶尔森氏菌毒力质粒上，但 Ail、Inv、LPS 和 ECA 是染色体编码的。这些结构确保了 OM 的正确结构，提供了粘附特性以及对抗菌肽和宿主先天免疫反应机制的抗性。
