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野猪分离株中抗菌药物耐药性及致病基因存在情况的证据

Evidence of Antimicrobial Resistance and Presence of Pathogenicity Genes in Isolate from Wild Boars.

作者信息

Modesto Paola, De Ciucis Chiara Grazia, Vencia Walter, Pugliano Maria Concetta, Mignone Walter, Berio Enrica, Masotti Chiara, Ercolini Carlo, Serracca Laura, Andreoli Tiziana, Dellepiane Monica, Adriano Daniela, Zoppi Simona, Meloni Daniela, Razzuoli Elisabetta

机构信息

Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, Italy.

Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Nizza 4, 18100 Imperia, Italy.

出版信息

Pathogens. 2021 Mar 27;10(4):398. doi: 10.3390/pathogens10040398.

Abstract

() is a very important zoonosis andwild boars play a pivotal role in its transmission. In the last decade, the wild boar population has undergone a strong increase that haspushed them towards urbanized areas, facilitating the human-wildlife interface and the spread of infectious diseases from wildlife to domestic animals and humans. Therefore, it is important to know the serotype, antimicrobial resistance and presence of pathogenicity genes of () isolated in species. From 2013 to 2018, we analyzed the liver of 4890 wild boars hunted in Liguria region; we isolated and serotyped 126 positive samples. A decisive role in the pathogenicity is given by the presence of virulence genes; in isolated we found (70%), (45.2%), (43.6%) and (20%). Moreover, we evaluated the susceptibility at various antimicrobic agents (Ampicillin, Chloramphenicol, Enrofloxacin, Gentamicin, Kanamycin, Trimethoprim-Sulfamethoxazole, Sulfisoxazole, Ceftiofur and Tetracycline). The antibiotic resistance was analyzed, and we found a time-dependent increase. It is important to shed light on the role of the wild boars as a reserve of potentially dangerous diseases for humans, and also on the antibiotic resistance that represents a public health problem.

摘要

()是一种非常重要的人畜共患病,野猪在其传播中起着关键作用。在过去十年中,野猪数量急剧增加,促使它们向城市化地区扩散,这促进了人类与野生动物的接触以及传染病从野生动物向家畜和人类的传播。因此,了解从物种中分离出的()的血清型、抗菌耐药性和致病性基因的存在情况非常重要。2013年至2018年,我们分析了在利古里亚地区猎杀的4890头野猪的肝脏;我们分离并血清分型了126份阳性样本。毒力基因的存在对致病性起决定性作用;在分离出的样本中,我们发现了(约70%)、(45.2%)、(43.6%)和(约20%)。此外,我们评估了各种抗菌剂(氨苄青霉素、氯霉素、恩诺沙星、庆大霉素、卡那霉素、甲氧苄啶-磺胺甲恶唑、磺胺异恶唑、头孢噻呋和四环素)的敏感性。分析了抗生素耐药性,我们发现其呈时间依赖性增加。阐明野猪作为对人类潜在危险疾病储备库的作用以及代表公共卫生问题的抗生素耐药性很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401a/8065425/294bc38322b1/pathogens-10-00398-g001.jpg

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