Rodriguez-Devora Jorge I, Ambure Sunny, Shi Zhi-Dong, Yuan Yuyu, Sun Wei, Xui Tao
Biomedical Engineering Program & Department of Mechanical Engineering, University of Texas at El Paso, El Paso, Texas 79968, USA.
Ther Deliv. 2012 Jan;3(1):125-39. doi: 10.4155/tde.11.137.
Facilitated/modulated drug-delivery systems have emerged as a possible solution for delivery of drugs of interest to pre-allocated sites at predetermined doses for predefined periods of time. Over the past decade, the use of different physical methods and mechanisms to mediate drug release and delivery has grown significantly. This emerging area of research has important implications for development of new therapeutic drugs for efficient treatments. This review aims to introduce and describe different modalities of physically facilitating drug-delivery systems that are currently in use for cancer and other diseases therapy. In particular, delivery methods based on ultrasound, electrical, magnetic and photo modulations are highlighted. Current uses and areas of improvement for these different physically facilitating drug-delivery systems are discussed. Furthermore, the main advantages and drawbacks of these technologies reviewed are compared. The review ends with a speculative viewpoint of how research is expected to evolve in the upcoming years.
促进/调控药物递送系统已成为一种可能的解决方案，可在预定时间段内以预定剂量将感兴趣的药物递送至预先分配的部位。在过去十年中，利用不同物理方法和机制来介导药物释放和递送的情况显著增加。这一新兴研究领域对开发高效治疗的新型治疗药物具有重要意义。本综述旨在介绍和描述目前用于癌症和其他疾病治疗的物理促进药物递送系统的不同模式。特别强调了基于超声、电、磁和光调制的递送方法。讨论了这些不同物理促进药物递送系统的当前用途和改进领域。此外，还比较了所综述的这些技术的主要优点和缺点。综述最后以一种推测性的观点展望了未来几年该研究的发展方向。
