"tet(U)" 不是四环素抗性决定簇。
"tet(U)" is not a tetracycline resistance determinant.
机构信息
Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2012 Jun;56(6):3378-9. doi: 10.1128/AAC.05957-11. Epub 2012 Apr 9.
Abstract
The enterococcal plasmid pKQ10 has been reported to carry a poorly characterized tetracycline resistance determinant designated tet(U). However, in a series of studies intended to further characterize this determinant, we have been unable to substantiate the claim that tet(U) confers resistance to tetracyclines. In line with these results, bioinformatic analysis provides compelling evidence that "tet(U)" is in fact the misannotated 3' end of a gene encoding a rolling-circle replication initiator (Rep) protein.
摘要
肠球菌质粒 pKQ10 曾被报道携带一种特征不明确的四环素抗性决定簇，被命名为 tet(U)。然而，在一系列旨在进一步对该决定簇进行表征的研究中，我们无法证实 tet(U)赋予了对抗生素四环素的抗性。与这些结果一致，生物信息学分析提供了有力的证据表明，“tet(U)”实际上是编码滚环复制起始蛋白（Rep）的基因的错误注释的 3'端。
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本文引用的文献
1
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.
BMC Genomics. 2010 Apr 14;11:239. doi: 10.1186/1471-2164-11-239.
2
The tetracycline resistome.
Cell Mol Life Sci. 2010 Feb;67(3):419-31. doi: 10.1007/s00018-009-0172-6. Epub 2009 Oct 28.
3
Presence of pRI1: a small cryptic mobilizable plasmid isolated from Enterococcus faecium of human and animal origin.
Curr Microbiol. 2009 Feb;58(2):95-100. doi: 10.1007/s00284-008-9266-x. Epub 2008 Oct 2.
4
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
Antimicrob Agents Chemother. 2007 Jan;51(1):231-8. doi: 10.1128/AAC.00576-06. Epub 2006 Oct 30.
5
Protein production by auto-induction in high density shaking cultures.
Protein Expr Purif. 2005 May;41(1):207-34. doi: 10.1016/j.pep.2005.01.016.
6
Update on acquired tetracycline resistance genes.
FEMS Microbiol Lett. 2005 Apr 15;245(2):195-203. doi: 10.1016/j.femsle.2005.02.034.
7
Rolling-circle replication of bacterial plasmids.
Microbiol Mol Biol Rev. 1997 Dec;61(4):442-55. doi: 10.1128/mmbr.61.4.442-455.1997.
8
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Plasmid. 1996 Mar;35(2):71-80. doi: 10.1006/plas.1996.0009.
9
Purification and characterization of Tet(M), a protein that renders ribosomes resistant to tetracycline.
J Biol Chem. 1991 Feb 15;266(5):2872-7.
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