"tet(U)" 不是四环素抗性决定簇。
"tet(U)" is not a tetracycline resistance determinant.
机构信息
Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2012 Jun;56(6):3378-9. doi: 10.1128/AAC.05957-11. Epub 2012 Apr 9.
Abstract
The enterococcal plasmid pKQ10 has been reported to carry a poorly characterized tetracycline resistance determinant designated tet(U). However, in a series of studies intended to further characterize this determinant, we have been unable to substantiate the claim that tet(U) confers resistance to tetracyclines. In line with these results, bioinformatic analysis provides compelling evidence that "tet(U)" is in fact the misannotated 3' end of a gene encoding a rolling-circle replication initiator (Rep) protein.
摘要
肠球菌质粒 pKQ10 曾被报道携带一种特征不明确的四环素抗性决定簇，被命名为 tet(U)。然而，在一系列旨在进一步对该决定簇进行表征的研究中，我们无法证实 tet(U)赋予了对抗生素四环素的抗性。与这些结果一致，生物信息学分析提供了有力的证据表明，“tet(U)”实际上是编码滚环复制起始蛋白（Rep）的基因的错误注释的 3'端。
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