Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
J Breast Cancer. 2012 Mar;15(1):128-32. doi: 10.4048/jbc.2012.15.1.128. Epub 2012 Mar 28.
We describe a patient with breast cancer who relapsed with an extensive pulmonary lymphovascular tumor embolism. A 38-year-old female, who previously received neoadjuvant chemotherapy and curative resection of breast cancer, underwent adjuvant chemotherapy and was referred to the emergency room because of sudden-onset pleuritic chest pain lasting for 10 days. Despite a trial of empirical antibiotics, the chest pain and the extent of consolidative lung lesion on chest radiographs rapidly aggravated. We performed an open lung biopsy to confirm the etiology. The histopathological review revealed a hemorrhagic infarction caused by lymphovascular tumor emboli from a metastatic breast carcinoma. Palliative first-line chemotherapy was administered, consisting of ixabepilone and capecitabine, and the lung lesion improved markedly.
我们描述了一例乳腺癌复发并伴有广泛肺血管淋巴管瘤栓的患者。一位 38 岁女性，曾接受新辅助化疗和乳腺癌根治性切除术，随后接受辅助化疗，并因突发胸痛持续 10 天而被转至急诊室。尽管尝试了经验性抗生素治疗，但胸痛和胸部 X 线片上实变病变的范围迅速加重。我们进行了开胸肺活检以明确病因。组织病理学检查显示，转移性乳腺癌的血管淋巴管瘤栓引起的出血性梗死。给予姑息性一线化疗，包括伊沙匹隆和卡培他滨，肺部病变明显改善。
