Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Drug Des Devel Ther. 2021 Oct 27;15:4435-4443. doi: 10.2147/DDDT.S336372. eCollection 2021.
The study aimed to investigate the effects of 2% hyaluronic acid (HA) on corneal epithelial defect after pterygium surgery in comparison with the control group, measured in terms of the healing rate of corneal epithelial defect and pain score after surgery.
In this double-blind randomized clinical trial, fifty patients with primary pterygium were randomized into 2 groups: a control group or the group treated with a single topical application of 2% HA. Comprehensive ophthalmological examinations included measuring the area of corneal epithelium defect using ImageJ freeware and the pain score assessment after the operation.
The mean and SD of the area of epithelial defect measured on postoperative Day 0, 1, and 2 were 10.89 ± 1.33 mm, 5.04 ± 0.87mm, and 2.44 ± 0.74 mm for the HA group, and 11.14 ± 1.11 mm, 7.74 ± 1.17 mm, and 5.31 ± 1.15 mm for the control group, respectively. While the initial area of the defect on Day 0 was essentially the same for both groups ( = 0.478), the area of the defect in the HA group was significantly smaller on both Day 1 and Day 2 ( < 0.001, < 0.001), respectively. Similarly, the HA group exhibited a statistically significant higher rate of healing for the cornea epithelial defect over Day 0 and 1 compared to the control group (5.85 ± 0.89 mm/day vs 3.14 ± 1.28 mm/day, < 0.001), respectively. The median (range) pain scores were evaluated at Day 0 was 7 (4-10) in the HA group and 7 (3-10) in the control group ( = 0.953). There was no statistically significant difference between two groups ( > 0.05) for Days 1, 2, and 3.
A single topical application of 2% HA tended to accelerate the healing process of corneal epithelium defect after pterygium surgery without any observable adverse effects during short-term follow-up.
本研究旨在比较 2%透明质酸（HA）与对照组在翼状胬肉手术后对角膜上皮缺损的影响，通过测量角膜上皮缺损愈合率和术后疼痛评分来评估。
在这项双盲随机临床试验中，将 50 名原发性翼状胬肉患者随机分为两组：对照组或接受单次局部应用 2%HA 治疗的组。综合眼科检查包括使用 ImageJ 免费软件测量角膜上皮缺损面积和术后疼痛评分。
HA 组术后第 0、1 和 2 天上皮缺损面积的平均值和标准差分别为 10.89 ± 1.33mm、5.04 ± 0.87mm 和 2.44 ± 0.74mm，对照组分别为 11.14 ± 1.11mm、7.74 ± 1.17mm 和 5.31 ± 1.15mm。虽然两组在第 0 天的初始缺损面积基本相同（ = 0.478），但在第 1 天和第 2 天，HA 组的缺损面积明显更小（ < 0.001， < 0.001）。同样，HA 组在第 0 天和第 1 天的角膜上皮缺损愈合率明显高于对照组（5.85 ± 0.89mm/天 vs 3.14 ± 1.28mm/天， < 0.001）。HA 组第 0 天的中位数（范围）疼痛评分为 7（4-10），对照组为 7（3-10）（ = 0.953）。两组在第 1、2 和 3 天的疼痛评分均无统计学差异（ > 0.05）。
单次局部应用 2%HA 可加速翼状胬肉手术后角膜上皮缺损的愈合过程，在短期随访中未观察到明显的不良反应。
