Interfaculty Institute of Microbiology and Infection Medicine, University Hospital Tübingen, University of Tübingen, Elfriede-Aulhorn Straße 6, 72076 Tübingen, Germany.
Trends Microbiol. 2012 May;20(5):243-50. doi: 10.1016/j.tim.2012.03.004. Epub 2012 Apr 9.
Approximately 20% of the healthy human population is persistently colonized in the nasal cavity with Staphylococcus aureus, which constitutes a major risk for infection. S. aureus seems to predominantly colonize the anterior part of the nasal cavity by adhering to nasal surface structures and escaping the host innate and adaptive immune responses. Several bacterial and host factors that play a role in these processes have been identified in the past few years and were in part functionally evaluated in appropriate colonization models. However, the dynamics of host-pathogen crosstalk is only partially understood.
约 20%的健康人群的鼻腔中会持续定植金黄色葡萄球菌，这构成了感染的主要风险。金黄色葡萄球菌似乎通过黏附于鼻腔表面结构并逃避宿主固有和适应性免疫反应，主要定植于鼻腔前部。过去几年中已经鉴定出在这些过程中起作用的几种细菌和宿主因素，并在部分合适的定植模型中对其功能进行了评估。然而，宿主-病原体相互作用的动态仅部分被理解。
