通过非同位素原位杂交将人类II型胶原基因（COL2A1）定位到染色体12（q13.1）的近端。
Mapping of the human type II collagen gene (COL2A1) proximal to fra(12) (q13.1) by nonisotopic in situ hybridization.
作者信息
Takahashi E, Hori T, Sutherland G R
机构信息
Division of Genetics, National Institute of Radiological Sciences, Chiba, Japan.
出版信息
Cytogenet Cell Genet. 1990;54(1-2):84-5. doi: 10.1159/000132965.
PMID:2249483
Abstract
The human type II collagen gene (COL2A1) was mapped to chromosome 12 immediately proximal to fra(12)(q13.1) by the technique of nonisotopic (biotinylated) in situ hybridization. Thus, the COL2A1 gene was confirmed to be at the subband 12q13.11----q13.12, in agreement with previous reports. These results are not in agreement with the localization (12q14.3) cited in Ropers and Craig (1989).
摘要
通过非同位素（生物素化）原位杂交技术，将人类Ⅱ型胶原基因（COL2A1）定位到12号染色体上，紧邻fra(12)(q13.1)。因此，COL2A1基因被证实位于12q13.11----q13.12亚带，与先前的报道一致。这些结果与Ropers和Craig（1989年）引用的定位（12q14.3）不一致。
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