Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA.
Nat Rev Genet. 2012 Apr 12;13(5):315-28. doi: 10.1038/nrg3187.
Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.
疟疾是一种重要的人类疾病，也是全球消除运动的目标。人口基因组学中的新技术和信息学进展正在被利用来识别疟原虫中受选择影响的遗传基因座，并找到与关键临床表型（如耐药性）相关的变异。本文及时地综述了基于种群遗传学的策略如何应用于恶性疟原虫，以确定遗传基因座作为干预的关键靶点，并开发监测和监督工具，这对于成功消除和根除疟疾至关重要。
