Robinson Gail A, Campbell Lara, Ceslis Amelia
Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Neuropsychology Research Unit, School of Psychology, The University of Queensland, Brisbane 4072, Australia.
Medicines (Basel). 2021 Mar 22;8(3):15. doi: 10.3390/medicines8030015.
: Parkinson's disease [PD] is associated with reduced motor and cognitive initiation, and decreased goal-directed behavior including language generation. The current study investigated a novel goal intervention for language generation impairments in PD patients. Twenty-one PD patients and 22 healthy controls, matched for gender, age, and education, completed a cognitive baseline and language generation tasks (complex scene descriptions and phonemic/semantic word fluency) with standard and adapted instructions, which implements a target 'goal'. In addition, participants completed self-report questionnaires for apathy and mood. PD patients performed more poorly on two of three language generation tasks. The goal intervention was effective in increasing both the PD patient and healthy control groups' language generation. However, there was no differential benefit of increased goal specificity and difficulty for PD patients. As a group, PD patients reported higher levels of apathy and depression than healthy controls. Specifically, PD patients with executive apathy were more likely to have language generation impairments than PD patients without executive apathy and controls. Apathy subscales and goal benefit were unrelated. The goal intervention was effective for PD patients and older adults, suggesting that enhanced goal specificity and difficulty may benefit individuals with PD or those aging naturally.
帕金森病（PD）与运动和认知启动减少以及包括语言产生在内的目标导向行为减少有关。本研究调查了一种针对PD患者语言产生障碍的新型目标干预措施。21名PD患者和22名年龄、性别和教育程度相匹配的健康对照者完成了认知基线和语言产生任务（复杂场景描述以及音素/语义词汇流畅性），任务采用了标准和调整后的指导语，其中实施了一个目标“导向”。此外，参与者还完成了关于冷漠和情绪的自我报告问卷。PD患者在三项语言产生任务中的两项表现较差。目标干预有效地提高了PD患者组和健康对照组的语言产生能力。然而，目标特异性和难度的增加对PD患者并没有差异优势。总体而言，PD患者报告的冷漠和抑郁水平高于健康对照者。具体来说，有执行性冷漠的PD患者比没有执行性冷漠的PD患者及对照组更有可能存在语言产生障碍。冷漠分量表与目标效益无关。目标干预对PD患者和老年人有效，这表明增强目标特异性和难度可能使PD患者或自然衰老的个体受益。
