非联会酵母中的减数分裂。
Meiosis in asynaptic yeast.
作者信息
Rockmill B, Roeder G S
机构信息
Department of Biology, Yale University, New Haven, Connecticut 06511-8112.
出版信息
Genetics. 1990 Nov;126(3):563-74. doi: 10.1093/genetics/126.3.563.
Abstract
The Saccharomyces cerevisiae red1 mutant fails to assemble synaptonemal complex during meiotic prophase. This mutant displays locus-specific reductions in interchromosomal gene conversion and a moderate reduction in crossing over. The occurrence of a significant amount of meiotically induced recombination in the red1 mutant indicates that the synaptonemal complex is not absolutely required for meiotic exchange. The RED1 gene product is required for intrachromosomal recombination in some assays but not others. Chromosomes that have undergone reciprocal exchange nevertheless nondisjoin in red1 mutants, indicating that crossovers are not sufficient for disjunction. Epistasis studies reveal that HOP1 is epistatic to RED1, and that RED1 acts in an independent pathway from MER1. A model for the function of the RED1 gene product in chromosome synapsis is discussed.
摘要
酿酒酵母red1突变体在减数分裂前期无法组装联会复合体。该突变体在染色体间基因转换中表现出特定位点的减少，并且在交叉互换中适度减少。red1突变体中大量减数分裂诱导的重组的发生表明，联会复合体对于减数分裂交换并非绝对必需。在某些试验中，RED1基因产物是染色体内重组所必需的，但在其他试验中并非如此。经历了相互交换的染色体在red1突变体中仍然不分离，这表明交叉互换不足以实现分离。上位性研究表明，HOP1对RED1是上位性的，并且RED1在一条独立于MER1的途径中起作用。文中讨论了RED1基因产物在染色体联会中的功能模型。
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