Immunology Department, Institute of Biomedical Science, University of São Paulo, SP, Brazil.
Obes Rev. 2012 Aug;13(8):733-43. doi: 10.1111/j.1467-789X.2012.00997.x. Epub 2012 Apr 12.
Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.
饮食摄入和营养状况会改变免疫系统对疾病和感染的生理反应，并调节慢性炎症过程的发展，如肾脏疾病。脂肪组织分泌称为脂肪因子的免疫相关蛋白，这些蛋白对免疫和神经内分泌系统具有多效性作用，将代谢和免疫生理学联系起来。瘦素是一种源自脂肪组织的脂肪因子，具有多种免疫和生理功能，并参与多种免疫反应。在这里，我们回顾了关于瘦素在肾脏疾病中的作用的现有文献，将脂肪组织和免疫系统与与肾脏相关的疾病联系起来。这种脂肪激素的调节可能对治疗几种与免疫和代谢相关的肾脏疾病产生重大影响。
