Department of Swine Diseases, National Veterinary Research Institute, Partyzantów 57, 24-100 Pulawy, Poland.
Vet J. 2012 Oct;194(1):128-30. doi: 10.1016/j.tvjl.2012.03.009. Epub 2012 Apr 10.
The effects of age and maternally-derived antibodies (MDA) on the immune response to Erysipelothrix rhusiopathiae were investigated in piglets orally vaccinated with a live E. rhusiopathiae vaccine at 6, 8 or 10 weeks of age. Seroconversion, determined by ELISA, was evident in MDA positive piglets vaccinated at 8 or 10 weeks of age and in all MDA negative vaccinates. Two weeks after vaccination in the presence of MDA, a T cell response, measured by a lymphocyte proliferation assay, was observed in 25% of piglets vaccinated at 6 weeks of age and in 100% of piglets vaccinated at 8 or 10 weeks of age. The post-vaccinal response to E. rhusiopathiae was more strongly influenced by the maternal antibody status of the piglet at the time of vaccination than the age of the piglet.
本研究旨在探讨仔猪年龄和母源抗体（MDA）对感染红斑丹毒丝菌后免疫应答的影响。实验中，6、8 或 10 周龄的仔猪经口接种红斑丹毒丝菌活疫苗。通过 ELISA 检测血清抗体转化情况，结果显示 8 或 10 周龄 MDA 阳性仔猪以及所有 MDA 阴性仔猪均发生了血清抗体转化。在 MDA 存在的情况下，接种后 2 周，通过淋巴细胞增殖试验检测到 T 细胞应答，结果显示 6 周龄仔猪中有 25%、8 或 10 周龄仔猪中有 100%发生了 T 细胞应答。疫苗接种时仔猪的 MDA 状态对其接种后的免疫应答影响更大，而仔猪的年龄影响较小。
