Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Med Virol. 2012 Jun;84(6):901-5. doi: 10.1002/jmv.23274.
This study reports the detection and the genetic characterization of HBoV, a new member in the Parvoviridae family. Among 177 fecal specimens collected from children with diarrhea younger than 5 years in Japan, 11 (6.2%) were positive for HBoV. Co-infection with other enteric viruses (norovirus and adenovirus) was found in nine (81.8%) pediatric patients, while monoinfection by HBoV alone was detected in two (18.2%) cases. Nucleotide sequence analysis of 11 Japanese HBoV strains revealed that seven HBoV sequences were most closely related to other HBoV 1 reference strains, while the other four strains were similar to HBoV 2A. These results indicated that HBoV was one of the viral agents found in stool specimens collected from children with acute gastroenteritis and HBoV 1 and 2A circulated in Japan between 2009 and 2010 epidemic season.
本研究报告了 HBoV 的检测和基因特征，HBoV 是细小病毒科的一个新成员。在日本采集的 177 份 5 岁以下腹泻儿童粪便样本中，有 11 份（6.2%） HBoV 阳性。在 9 名（81.8%）儿科患者中发现了与其他肠道病毒（诺如病毒和腺病毒）的合并感染，而单独的 HBoV 单一感染在 2 名（18.2%）患者中检测到。对 11 株日本 HBoV 株的核苷酸序列分析表明，7 株 HBoV 序列与其他 HBoV1 参考株最为密切相关，而另外 4 株与 HBoV2A 相似。这些结果表明，HBoV 是从急性胃肠炎患儿粪便样本中发现的病毒之一，HBoV1 和 HBoV2A 在 2009 年至 2010 年流行季节在日本流行。
