Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi Province, China.
Pancreatology. 2011;11(2):92-8. doi: 10.1159/000327688. Epub 2011 May 17.
BACKGROUND/AIMS: It is generally accepted that there is a correlation between obesity and poor outcome in acute pancreatitis (AP); however, the relationship between overweight and the prognosis of AP is unknown. The aim of this study was to determine the correlation between overweight and the prognosis of AP.
MEDLINE and PubMed were searched using the terms 'acute pancreatitis', 'obesity', 'overweight', and 'body mass index' ('BMI'). All prospective clinical studies correlating BMI and AP were included. Obesity and overweight were defined as BMI ≥30 and from 25 to 30, respectively. A meta-analysis was performed with the endpoints severe AP (SAP), local complications, systemic complications, and mortality.
Eight studies including 939 patients were found. The incidence rates of SAP (OR 2.48, 95% CI 1.34-4.60), local complications (OR 2.58, 95% CI 1.20-5.57), and mortality (OR 3.81, 95% CI 1.22-11.83) were increased in overweight patients with AP. No difference was detected in the incidence of systemic complications between the normal-weight and overweight patients (OR 1.62, 95% CI 0.76-3.43). In addition, the correlation between obesity and poor prognosis was again confirmed.
Overweight is an additional prognostic factor of severity, local complications, and mortality in AP. and IAP.
背景/目的：肥胖与急性胰腺炎（AP）不良预后之间存在相关性已被广泛接受；然而，超重与 AP 预后之间的关系尚不清楚。本研究旨在确定超重与 AP 预后之间的相关性。
使用“急性胰腺炎”、“肥胖”、“超重”和“体重指数”（“BMI”）等术语在 MEDLINE 和 PubMed 上进行搜索。纳入所有与 BMI 和 AP 相关的前瞻性临床研究。肥胖和超重分别定义为 BMI≥30 和 25-30。采用荟萃分析，终点为重症急性胰腺炎（SAP）、局部并发症、全身并发症和死亡率。
共发现 8 项研究，纳入 939 例患者。超重 AP 患者 SAP（OR 2.48，95% CI 1.34-4.60）、局部并发症（OR 2.58，95% CI 1.20-5.57）和死亡率（OR 3.81，95% CI 1.22-11.83）的发生率增加。超重与正常体重 AP 患者的全身并发症发生率无差异（OR 1.62，95% CI 0.76-3.43）。此外，肥胖与不良预后之间的相关性再次得到证实。
超重是 AP 严重程度、局部并发症和死亡率的另一个预后因素。
