Francis D P, Cotter S M, Hardy W D, Essex M
Cancer Res. 1979 Oct;39(10):3866-70.
One hundred eighty-four cases of feline leukemia and lymphoma diagnosed in Boston from 1972 through 1976 were investigated. Fifty-eight % of these cases were lymphoma, and 42% were leukemia. Sixty-seven % of the cats had positive fluorescent antibody tests for circulating feline leukemia virus. The rest (33%) were virus negative. Clinically and epidemiologically, the virus-positive and virus-negative cases were remarkably similar except for their age at diagnosis. Virus-negative cats tended to be older (mean age at diagnosis, 4.9 years) as compared to virus-positive cats (3.5 years). For 22 cases of leukemia and lymphoma diagnosed after the age of 8 years, 15 were virus negative. The minimum mean induction period (time from first positive virus test to diagnosis of cancer) for 19 cats that were virus positive and healthy at their first test was 16.7 months (range, 2 to 41 months).
对1972年至1976年在波士顿诊断出的184例猫白血病和淋巴瘤病例进行了调查。这些病例中58%为淋巴瘤，42%为白血病。67%的猫循环猫白血病病毒荧光抗体检测呈阳性。其余（33%）病毒检测为阴性。在临床和流行病学方面，病毒阳性和病毒阴性病例除诊断时的年龄外，非常相似。与病毒阳性猫（3.5岁）相比，病毒阴性猫往往年龄更大（诊断时平均年龄4.9岁）。在8岁以后诊断出的22例白血病和淋巴瘤病例中，15例病毒检测为阴性。19只首次检测时病毒呈阳性且健康的猫，其最短平均诱导期（从首次病毒检测阳性到癌症诊断的时间）为16.7个月（范围为2至41个月）。
