National Institute for Medical Rehabilitation, H-1121 Budapest, Szanatórium u. 19, Hungary.
Epilepsy Behav. 2012 May;24(1):131-3. doi: 10.1016/j.yebeh.2012.03.011. Epub 2012 Apr 11.
There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.
人们对维生素 D 在各种医学病症中的作用越来越感兴趣，如糖尿病和肿瘤、心血管和中枢神经系统疾病。尽管众所周知，癫痫患者普遍存在维生素 D 缺乏症，但仅有一项近四十年前发表的研究评估了维生素 D 对控制癫痫发作的影响。在这里，我们测量了 13 名耐药性癫痫患者的血清 25-羟维生素 D（25(OH)D）水平，并通过给予维生素 D3 进行了校正。为了观察维生素 D3 是否对癫痫发作频率有影响，我们比较了治疗开始前后 90 天内的癫痫发作次数。我们发现，癫痫发作次数在补充维生素 D3 后明显减少。中位数癫痫发作减少了 40%。我们得出结论，血清维生素 25(OH)D 水平的正常化具有抗惊厥作用。
