Human Reproduction Research Program Unit, Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Nigeria.
Int J Gynaecol Obstet. 2012 Jul;118(1):56-60. doi: 10.1016/j.ijgo.2012.01.022. Epub 2012 Apr 12.
To assess the results of an in vitro fertilization program newly established within a conventional infertility program at a university hospital in Nigeria.
From June 1, 2007, to June 30, 2011, following unsuccessful conventional treatments, 600 couples were offered in vitro fertilization with (if needed) intracytoplasmic sperm injection in batches of 30 couples. The outcomes measured were duration of ovarian stimulation and rate of ovarian hyperstimulation syndrome; numbers of follicles aspirated, oocytes retrieved, oocytes fertilized, and embryos transferred; and clinical pregnancy rate.
The mean duration of stimulation was 11.8 ± 1.6 days and 1% of the women had severe ovarian hyperstimulation syndrome. The mean number of follicles aspirated was 8 ± 2.8; of oocytes retrieved 6 ± 3.2; and fertilized 3 ± 1.8. The maximum number of embryos transferred per woman was 3. The rates of clinical pregnancy and multiple pregnancy were 30% and 6.0%. The rates of abortion and ectopic pregnancy were 6.6% and 0.6%. The preterm delivery rate was 2.5%.
Successfully conducting an assisted reproduction program at a public health facility is feasible in a low-resource country. Treating couples in batches was cost effective, with a low complication rate.
评估在尼日利亚一所大学医院常规不孕不育项目中新设立的体外受精项目的结果。
从 2007 年 6 月 1 日至 2011 年 6 月 30 日，在常规治疗失败后，600 对夫妇分批次（如果需要）接受了 30 对夫妇的体外受精和（如果需要）胞浆内精子注射。测量的结果是卵巢刺激的持续时间和卵巢过度刺激综合征的发生率；卵泡抽吸数、卵母细胞采集数、卵母细胞受精数和胚胎移植数；以及临床妊娠率。
刺激的平均持续时间为 11.8 ± 1.6 天，有 1%的妇女患有严重的卵巢过度刺激综合征。平均抽吸卵泡数为 8 ± 2.8；卵母细胞采集数为 6 ± 3.2；受精数为 3 ± 1.8。每个妇女最大的胚胎移植数为 3。临床妊娠率和多胎妊娠率分别为 30%和 6.0%。流产率和异位妊娠率分别为 6.6%和 0.6%。早产率为 2.5%。
在资源匮乏的国家成功开展辅助生殖项目是可行的。分批治疗夫妇具有成本效益，并发症发生率低。
