中国高等真菌的次生代谢产物及其生物活性。

Secondary metabolites from higher fungi in China and their biological activity.

作者信息

Liu J K

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

出版信息

Drug Discov Ther. 2007 Oct;1(2):94-103.

PMID:22504394

Abstract

As a part of our search for naturally occurring bioactive metabolites from higher fungi, we investigated the chemical constituents of basidiomycetes and ascomycetes fungi (Albatrellus confluens, Albatrellus dispansus, Boletus edulis, Boletopsis grisea, Bondarzewia berkeleyi, Cortinarius tenuipes, Cortinarius vibratilis, Daldinia concentrica, Engleromyces goetzii, Hydnum repandum, Hebeloma versipelle, Hygrophorus eburnesus, Lactarius deliciosus, Lactarius hatsudake, Lactarius hirtipes, Lactarius mitissimus, Lactarius rufus, Paxillus panuoides, Pulveroboletus ravenelii, Russula cyanoxantha, Russula foetens, Russula lepida, Russula nigricans, Sarcodon laevigatum, Sarcodon scabrosus, Shiraia bambusicola, Thelephora aurantiotincta, Thelephora ganbajun, Tricholomopsis rutilans, Tylopilus virens, Tuber indicum, Xylaria euglossa, etc.), and isolated a number of novel terpenoids, phenolics, and nitrogen-containing compounds. The isolation, structural elucidation, and biologically activity of the new compounds are discussed.

摘要

作为我们从高等真菌中寻找天然存在的生物活性代谢物工作的一部分，我们研究了担子菌和子囊菌（融合白牛肝菌、分散白牛肝菌、美味牛肝菌、灰褐牛肝菌、伯克利牛舌菌、细柄丝膜菌、颤动丝膜菌、同心炭团菌、戈氏恩格勒菌、刺孢多孔菌、毒鹅膏、白黄粘盖牛肝菌、白霜杯伞、松乳菇、红汁乳菇、绒柄乳菇、温和乳菇、红乳菇、拟块菌牛肝菌、红绒盖牛肝菌、蓝黄红菇、恶臭红菇、美味红菇、黑红菇、光盖肉齿菌、粗糙肉齿菌、竹黄、橙黄革菌、干巴菌、金黄硬皮马勃菌、绿盖粉孢牛肝菌、毒粉褶菌、印度块菌、香木层孔菌等）的化学成分，并分离出了一些新型萜类化合物、酚类化合物和含氮化合物。本文讨论了这些新化合物的分离、结构解析及生物活性。