来自真菌戈氏恩格勒菌培养物的新型二萜类化合物及其对胆固醇酯转运蛋白的抑制活性。

Wang Yang, Zhang Ling, Wang Fang, Li Zheng-Hui, Dong Ze-Jun, Liu Ji-Kai

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Nat Prod Bioprospect. 2015 Apr 8;5(2):69-75. doi: 10.1007/s13659-015-0055-5.

One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

从真菌峨眉拟层孔菌（Engleromyces goetzii）的培养物中分离出一种名为恩格勒霉烯醇酸A（1）的新闭鞘姜烷型二萜、一种名为恩格勒霉烯醇酸B（2）的新蔷薇烷型二萜和一种新的天然蔷薇烷型二萜恩格勒霉醇（3），以及三种已知的蔷薇烷型二萜，玫瑰内酯（4）、玫瑰诺内酯（5）和7-脱氧玫瑰诺内酯（6）。峨眉拟层孔菌自然生长在高山竹茎上。根据它们的光谱数据对新化合物进行了鉴定。此外，还评估了化合物1-6对胆固醇酯转移蛋白（CETP）的抑制活性。本文报道了这些化合物的分离、结构鉴定及CETP抑制活性。