加拿大多伦多产超广谱β-内酰胺酶大肠埃希菌和肺炎克雷伯菌分离株对非碳青霉烯类抗菌药物敏感性降低。
Decreased susceptibility to noncarbapenem antimicrobials in extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in Toronto, Canada.
机构信息
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
出版信息
Antimicrob Agents Chemother. 2012 Jul;56(7):3977-80. doi: 10.1128/AAC.00260-12. Epub 2012 Apr 16.
Abstract
Retrospective review from 11 Canadian hospitals showed increasing incidence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae from 0.12 per 1,000 inpatient days during 2005 to 0.47 per 1,000 inpatient days during 2009. By 2009, susceptibility rates of ESBL-positive E. coli/K. pneumoniae were as follows: ciprofloxacin, 12.8%/9.0%; TMP/SMX, 32.9%/12.2%; and nitrofurantoin, 83.8%/10.3%. Nosocomial and nonnosocomial ESBL-producing E. coli isolates had similar susceptibility profiles, while nonnosocomial ESBL-producing K. pneumoniae was associated with decreased ciprofloxacin (P = 0.03) and nitrofurantoin (P < 0.001) susceptibilities.
摘要
11 家加拿大医院的回顾性研究显示，产超广谱β-内酰胺酶（ESBL）的大肠埃希菌和肺炎克雷伯菌的发病率从 2005 年的每 1000 个住院日 0.12 例上升到 2009 年的每 1000 个住院日 0.47 例。到 2009 年，产 ESBL 阳性大肠埃希菌/肺炎克雷伯菌的药敏率如下：环丙沙星，12.8%/9.0%；复方磺胺甲噁唑，32.9%/12.2%；呋喃妥因，83.8%/10.3%。医院内和非医院内产 ESBL 的大肠埃希菌分离株具有相似的药敏谱，而非医院内产 ESBL 的肺炎克雷伯菌与环丙沙星（P = 0.03）和呋喃妥因（P < 0.001）的敏感性降低有关。
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