Micro and Nanosystems, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland.
Philos Trans A Math Phys Eng Sci. 2012 May 28;370(1967):2418-32. doi: 10.1098/rsta.2011.0439.
A new generation of partially or even fully biodegradable implants is emerging. The idea of using temporary devices is to avoid a second surgery to remove the implant after its period of use, thereby improving considerably the patient's comfort and safety. This paper provides a state-of-the-art overview and an experimental section that describes the key technological challenges for making biodegradable devices. The general considerations for the design and synthesis of biodegradable components are illustrated with radiofrequency-driven resistor-inductor-capacitor (RLC) resonators made of biodegradable metals (Mg, Mg alloy, Fe, Fe alloys) and biodegradable conductive polymer composites (polycaprolactone-polypyrrole, polylactide-polypyrrole). Two concepts for partially/fully biodegradable wireless implants are discussed, the ultimate goal being to obtain a fully biodegradable sensor for in vivo sensing.
新一代部分或完全可生物降解的植入物正在出现。使用临时装置的想法是避免在使用期后进行第二次手术来移除植入物，从而极大地提高患者的舒适度和安全性。本文提供了最新的概述和实验部分，介绍了制造可生物降解装置的关键技术挑战。通过使用可生物降解金属（镁、镁合金、铁、铁合金）和可生物降解导电聚合物复合材料（聚己内酯-聚吡咯、聚乳酸-聚吡咯）制成的射频驱动电阻-电感-电容（RLC）谐振器，说明了可生物降解组件的设计和合成的一般考虑因素。讨论了两种部分/完全可生物降解无线植入物的概念，最终目标是获得用于体内传感的完全可生物降解传感器。
