Heath P J, Ogg T W, Gilks W R
Anaesthetic Department, Southampton General Hospital.
Anaesthesia. 1990 Nov;45(11):911-5. doi: 10.1111/j.1365-2044.1990.tb14617.x.
Sixty patients who presented for day-case dilatation and curettage were allocated randomly to receive either thiopentone or propofol for induction and maintenance of anaesthesia. One anaesthetist administered all the anaesthetics whilst all assessments were made by one other. The results indicate that early recovery of memory function, critical flicker fusion frequency and subjective feelings of tiredness, drowsiness and alertness were superior in the propofol group. There was a significant difference in subjective feelings of tiredness and drowsiness recorded by the two study groups at 24 hours. Memory function assessed by Wechsler logical memory function passages at 24 hours was impaired in the propofol group in comparison to a group of 'reference' subjects.
60名接受日间扩张刮宫术的患者被随机分配,分别接受硫喷妥钠或丙泊酚进行麻醉诱导和维持。由一名麻醉师实施所有麻醉,而所有评估由另一名人员进行。结果表明,丙泊酚组在记忆功能、临界闪烁融合频率以及疲劳、嗜睡和警觉性的主观感受方面的早期恢复情况更好。两个研究组在24小时记录的疲劳和嗜睡主观感受存在显著差异。与一组“参照”对象相比,丙泊酚组在24小时通过韦氏逻辑记忆功能段落评估的记忆功能受到损害。