Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China.
Molecules. 2012 Apr 20;17(4):4672-83. doi: 10.3390/molecules17044672.
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
该研究通过建立肝癌（HCC）大鼠模型，考察了丹皮酚的免疫和抗氧化潜力。三种剂量的丹皮酚（20、40、60mg/kg·bw 灌胃）被用于二乙基亚硝胺（DEN）诱导的 HCC 大鼠。结果表明，丹皮酚能显著降低 HCC 大鼠血清 AST、ALT、ALP、GGT、AFU 和肝 MDA 水平，增加血清 WBC、TP、ALB、A/G、TNF-α 和 IFN-γ以及肝抗氧化酶活性（SOD、CAT、GSH-Px、GR）。综上，这些结果表明丹皮酚能有效减轻 HCC 大鼠的氧化损伤，提高免疫功能。
