丹皮酚对肝癌大鼠抗氧化及免疫调节活性的影响。
Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.
机构信息
Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China.
出版信息
Molecules. 2012 Apr 20;17(4):4672-83. doi: 10.3390/molecules17044672.
Abstract
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
摘要
该研究通过建立肝癌（HCC）大鼠模型，考察了丹皮酚的免疫和抗氧化潜力。三种剂量的丹皮酚（20、40、60mg/kg·bw 灌胃）被用于二乙基亚硝胺（DEN）诱导的 HCC 大鼠。结果表明，丹皮酚能显著降低 HCC 大鼠血清 AST、ALT、ALP、GGT、AFU 和肝 MDA 水平，增加血清 WBC、TP、ALB、A/G、TNF-α 和 IFN-γ以及肝抗氧化酶活性（SOD、CAT、GSH-Px、GR）。综上，这些结果表明丹皮酚能有效减轻 HCC 大鼠的氧化损伤，提高免疫功能。
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