常见 blaOXA-24/OXA-40 携带平台和质粒在鲍曼不动杆菌临床分离株中 OXA-24/OXA-40 传播中的作用。
Role of common blaOXA-24/OXA-40-carrying platforms and plasmids in the spread of OXA-24/OXA-40 among Acinetobacter species clinical isolates.
机构信息
REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
出版信息
Antimicrob Agents Chemother. 2012 Jul;56(7):3969-72. doi: 10.1128/AAC.06255-11. Epub 2012 Apr 23.
Abstract
The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla(OXA-24/40)-carrying plasmids and genetic environments were characterized in representative (n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla(OXA-24/40) within the chromosomes of some isolates, the circulation of common bla(OXA-24/40)-carrying plasmids (30-kb repA_AB; 10-kb aci2) and genetic backbones among Acinetobacter spp. was demonstrated.
摘要
产 OXA-24/OXA-40（OXA-24/40）型不动杆菌在伊比利亚半岛的传播受到克隆扩张的强烈影响，但水平基因转移的作用几乎没有被探索过。通过基于 PCR 的鲍曼不动杆菌复制子分型、测序、杂交和限制性片段长度多态性，对 15 株具有代表性的（2001 年至 2007 年间获得）临床分离的不动杆菌种属临床分离株中的 bla（OXA-24/40）携带质粒和遗传环境进行了特征描述。除了在一些分离株的染色体中鉴定出 bla（OXA-24/40）之外，还证明了 bla（OXA-24/40）携带质粒（30-kb repA_AB；10-kb aci2）和不动杆菌属之间遗传骨架的循环。
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