University of Colorado School of Medicine, Denver, CO, USA.
Curr Diab Rep. 2012 Jun;12(3):305-13. doi: 10.1007/s11892-012-0274-7.
Diabetes causes cardiomyopathy, both directly and by potentiating the effect of its common comorbidities, coronary artery disease and hypertension, on its development. With the common and growing prevalence of diabetes worldwide, diabetic cardiomyopathy is a significant public health problem. Recent research identifies both mitochondrial dysfunction and epigenetic effects as newly recognized factors in the complex pathogenesis of diabetic cardiomyopathy. Diagnostically, specialized echocardiography techniques, cardiac magnetic resonance imaging, and serologic biomarkers all appear to have promise in detecting the early stages of diabetic cardiomyopathy. Research into treatments includes both traditional diabetes and heart failure therapies, but also explores the potential of newer metabolic and anti-inflammatory agents. These recent insights provide important additions to our knowledge about diabetic cardiomyopathy, but much remains unknown.
糖尿病可导致心肌病，既可以直接导致，也可以通过加剧其常见合并症（如冠状动脉疾病和高血压）对其发展的影响导致。随着糖尿病在全球的普遍和不断增长的流行，糖尿病性心肌病已成为一个重大的公共卫生问题。最近的研究发现，线粒体功能障碍和表观遗传效应是糖尿病性心肌病复杂发病机制中的新认识因素。在诊断方面，专门的超声心动图技术、心脏磁共振成像和血清生物标志物似乎都有希望检测到糖尿病性心肌病的早期阶段。治疗研究包括传统的糖尿病和心力衰竭治疗方法，还探索了新型代谢和抗炎药物的潜力。这些最近的研究进展为我们对糖尿病性心肌病的认识提供了重要补充，但仍有许多未知之处。
