López-Valverde Nansi, López-Valverde Antonio, Ramírez Juan Manuel
Department of Surgery, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.
Department of Morphological Sciences, University of Cordoba, Avenida Menéndez Pidal s/n, 14071 Cordoba, Spain.
Biology (Basel). 2021 Feb 1;10(2):102. doi: 10.3390/biology10020102.
Chitosan is a natural polysaccharide extracted from the shells of crustaceans that has been proposed as a scaffold in tissue engineering. Certain studies have proven a greater osseointegration of titanium surfaces that are functionalized with chitosan. The MEDLINE, CENTRAL, PubMed, and Web of Science databases were electronically searched for in vivo studies. Seven studies met the inclusion criteria. Animal models, implant site, chitosan incorporation methods, and methods of analysis were emphasized. The selected studies were individually discussed regarding the coatings, osseointegration potential, and suitability of the experimental models used, analyzing their limitations. We concluded that chitosan-biofunctionalized titanium surfaces have greater osseointegration capacity that uncoated control titanium alloys.
壳聚糖是一种从甲壳类动物外壳中提取的天然多糖，已被提议作为组织工程中的支架材料。某些研究已证实，用壳聚糖功能化的钛表面具有更强的骨整合能力。通过电子检索MEDLINE、CENTRAL、PubMed和科学网数据库查找体内研究。七项研究符合纳入标准。重点介绍了动物模型、植入部位、壳聚糖掺入方法和分析方法。针对所选研究，分别讨论了涂层、骨整合潜力以及所用实验模型的适用性，并分析了其局限性。我们得出结论，壳聚糖生物功能化的钛表面比未涂层的对照钛合金具有更强的骨整合能力。
