泰国传统医学植物作为抵抗修饰剂，用于对抗鲍曼不动杆菌感染。
Thai ethnomedicinal plants as resistant modifying agents for combating Acinetobacter baumannii infections.
机构信息
Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
出版信息
BMC Complement Altern Med. 2012 Apr 26;12:56. doi: 10.1186/1472-6882-12-56.
BACKGROUND
Acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.
METHODS
Fifty-one ethanol extracts obtained from 44 different selected medicinal plant species were tested for resistance modifying agents (RMAs) of novobiocin against A. baumannii using growth inhibition assay.
RESULTS
At 250 μg/ml, Holarrhena antidysenterica, Punica granatum, Quisqualis indica, Terminalia bellirica, Terminalia chebula, and Terminalia sp. that possessed low intrinsic antibacterial activity significantly enhanced the activity of novobiocin at 1 μg/ml (1/8xminimum inhibitory concentration) against this pathogen. Holarrhena antidysenterica at 7.8 μg/ml demonstrated remarkable resistant modifying ability against A. baumannii in combination with novobiocin. The phytochemical study revealed that constituents of this medicinal plant contain alkaloids, condensed tannins, and triterpenoids.
CONCLUSION
The use of Holarrhena antidysenterica in combination with novobiocin provides an effective alternative treatment for multidrug resistant A. baumannii infections.
背景
鲍曼不动杆菌是一种公认的重要医院病原体，然而，由于其对几种抗生素的固有耐药性，治疗选择有限。抗生素和药用植物之间的协同作用，特别是它们的活性成分，已作为替代方法进行了深入研究。
方法
使用生长抑制试验，测试了从 44 种不同选定药用植物中获得的 51 种乙醇提取物对新生霉素的耐药调节剂（RMA）对鲍曼不动杆菌的作用。
结果
在 250μg/ml 时，内在抗菌活性低的 Holarrhena antidysenterica、Punica granatum、Quisqualis indica、Terminalia bellirica、Terminalia chebula 和 Terminalia sp. 显著增强了新生霉素在该病原体 1μg/ml（1/8x 最小抑菌浓度）下的活性。Holarrhena antidysenterica 在 7.8μg/ml 时与新生霉素联合显示出对鲍曼不动杆菌具有显著的耐药修饰能力。植物化学研究表明，这种药用植物的成分含有生物碱、缩合单宁和三萜类化合物。
结论
将 Holarrhena antidysenterica 与新生霉素联合使用为治疗多重耐药鲍曼不动杆菌感染提供了一种有效的替代治疗方法。
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