Department of Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Division of Microbiology and NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar 751023, Odisha, India.
Biomolecules. 2020 Sep 18;10(9):1341. doi: 10.3390/biom10091341.
is an important medicinal plant of the Apocynaceae family that is widely distributed over the Indian subcontinent. The plant is extensively used in Ayurveda and other traditional medicinal systems without obvious adverse effects. Beside notable progress in the biological and phytochemical evaluation of this plant over the past few years, comprehensive reviews of are limited in scope. It has economic importance due to the extensive use of seeds as an antidiabetic. Furthermore, the plant is extensively reported in traditional uses among the natives of Asia and Africa, while scientifical validation for various ailments has not been studied either in vitro or in vivo. This review aims to summarize information on the pharmacology, traditional uses, active constituents, safety and toxicity of . Chemical analysis of extracts revealed the presence of several bioactive compounds, such as conessine, isoconnessine, conessimine, conimine, conessidine, conkurchicine, holarrhimine, conarrhimine, mokluangin A-D and antidysentericine. Overall, this review covers the ethnopharmacology, phytochemical composition, and pharmacological potential of with a critical discussion of its toxicity, biological activities (in vitro and in vivo), the mechanism of action, as well as suggestions for further basic and clinical research.
是夹竹桃科的一种重要药用植物，广泛分布于印度次大陆。该植物在阿育吠陀和其他传统医学系统中被广泛使用，没有明显的不良反应。除了过去几年对这种植物的生物学和植物化学评价有显著进展外，对 的综合评价范围有限。由于种子被广泛用作抗糖尿病药物，该植物具有经济重要性。此外，该植物在亚洲和非洲的当地人的传统用途中被广泛报道，而对各种疾病的科学验证无论是在体外还是体内都没有研究过。本综述旨在总结 的药理学、传统用途、活性成分、安全性和毒性信息。对 提取物的化学分析表明存在几种生物活性化合物，如 conessine、isoconnessine、conessimine、conimine、conessidine、conkurchicine、holarrhimine、conarrhimine、mokluangin A-D 和 antidysentericine。总的来说，本综述涵盖了 的民族药理学、植物化学组成和药理学潜力，并对其毒性、生物活性（体外和体内）、作用机制以及进一步的基础和临床研究提出了建议。
