Arushanian E B, Shchetinin E V, Baturin V A
Farmakol Toksikol. 1990 Sep-Oct;53(5):64-7.
Rats with different rhythmical structure of forced swimming had different susceptibility to antidepressant drugs. The drugs equally changed only the rhythmical index of depression but not other swimming parameters in sensible animals. As suggested, the assessment of swimming time-course can be used for antidepressant screening and preliminary selection of drug-resistant animals.
具有不同强迫游泳节律结构的大鼠对抗抑郁药物的敏感性不同。在敏感动物中，这些药物仅同等程度地改变了抑郁的节律指标，而未改变其他游泳参数。研究表明，游泳时间进程评估可用于抗抑郁药物筛选及耐药动物的初步筛选。
