Department of Dermatology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Br J Dermatol. 2012 Sep;167(3):542-7. doi: 10.1111/j.1365-2133.2012.11020.x. Epub 2012 Jul 19.
The cell surface protein CD93, expressed on endothelial and myeloid cells, mediates phagocytosis, inflammation and cell adhesion. A soluble form of CD93 (sCD93) is released during inflammation.
To determine the serum sCD93 level and its association with clinical parameters in patients with systemic sclerosis (SSc).
Serum sCD93 levels were examined by enzyme-linked immunosorbent assay in 59 patients with SSc, 24 patients with systemic lupus erythematosus and 47 healthy individuals. The expression of CD93 in skin tissues was examined immunohistochemically. In a retrospective longitudinal study, sera from 11 patients with SSc were analysed.
Serum sCD93 levels were increased in patients with SSc compared with healthy individuals (P<0·001). Patients with diffuse cutaneous SSc showed greater levels of sCD93 than those with limited cutaneous SSc (P<0·01) or systemic lupus erythematosus (P<0·01). Serum sCD93 levels correlated positively with the severity of skin sclerosis. Strong CD93 immunostaining was observed on endothelial cells in lesional skin tissues. In the longitudinal study, sCD93 levels decreased in parallel with improvement in skin sclerosis.
Serum sCD93 levels are increased in patients with SSc and correlate with the severity and activity of skin sclerosis. CD93 may contribute to the development of skin fibrosis in SSc.
细胞表面蛋白 CD93 表达于内皮细胞和髓样细胞，介导吞噬作用、炎症和细胞黏附。CD93 的可溶性形式（sCD93）在炎症期间释放。
测定系统性硬化症（SSc）患者血清 sCD93 水平及其与临床参数的相关性。
采用酶联免疫吸附试验检测 59 例 SSc 患者、24 例系统性红斑狼疮患者和 47 名健康对照者的血清 sCD93 水平。采用免疫组织化学法检测皮肤组织中 CD93 的表达。在一项回顾性纵向研究中，分析了 11 例 SSc 患者的血清。
与健康对照者相比，SSc 患者血清 sCD93 水平升高（P<0·001）。弥漫性皮肤 SSc 患者的 sCD93 水平高于局限性皮肤 SSc 患者（P<0·01）或系统性红斑狼疮患者（P<0·01）。血清 sCD93 水平与皮肤硬化的严重程度呈正相关。病变皮肤组织中内皮细胞 CD93 免疫染色强阳性。在纵向研究中，sCD93 水平随皮肤硬化的改善而平行下降。
SSc 患者血清 sCD93 水平升高，与皮肤硬化的严重程度和活动度相关。CD93 可能有助于 SSc 皮肤纤维化的发生。
