São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil.
Diabetol Metab Syndr. 2010 Jun 23;2:43. doi: 10.1186/1758-5996-2-43.
Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.
Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.
The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.
Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.
基于果糖的饮食显然与多种代谢功能紊乱的发生有关，但大量摄入果糖对身体组织的影响尚未得到很好的描述。本研究旨在分析慢性摄入富含果糖的软饮料后大鼠不同组织的一般特征和脂质含量。
使用 45 只 Wistar 大鼠。将大鼠分为三组（每组 15 只），允许它们在 8 周内仅饮用纯水（C）、淡可口可乐（R）（L）或普通可口可乐（R）（R）作为液体的唯一来源。
R 组的每日液体摄入量明显高于 C 组和 L 组，而食物摄入量明显低于 C 组和 L 组。此外，与 C 组和 L 组相比，R 组血清和肝脏中的甘油三酯浓度更高。然而，L 组动物的血清甘油三酯和胆固醇值低于对照组。
根据结果，可以得出结论，每天摄入大量富含果糖的软饮料会导致大鼠的脂质谱发生不利变化。
