Department of Neurology, University of Münster, Münster, Germany Department of Neurology, University of Munich, München, Germany Department of Prosthodontics, University of Münster, Münster, Germany Department of Anaesthesiology, University of Münster, Münster, Germany Department of Orthopaedics and Tumororthopaedics, University of Münster, Münster, Germany Eye Hospital, University of Münster, Münster, Germany.
Pain. 2012 Jun;153(6):1210-1218. doi: 10.1016/j.pain.2012.02.025. Epub 2012 Apr 25.
Recently, a self-rating measure for pain perception based on imagined painful daily life situations, the Pain Sensitivity Questionnaire (PSQ), has been developed and shown to correlate with experimentally obtained pain intensity ratings in healthy subjects. Here, we assessed the validity of the PSQ for investigation of general pain perception (ie, pain perception outside the site of clinical pain) in chronic pain patients. PSQ scores were obtained in 134 chronic pain patients and compared to those of 185 healthy control subjects. In a subgroup of 46 chronic pain patients, we performed experimental pain testing outside the clinical pain site, including different modalities (heat, cold, pressure, and pinprick) and different measures (pain thresholds, pain intensity ratings). Results show that PSQ scores were significantly correlated with both experimental pain intensity ratings (Pearson's r=0.71, P<.001) and experimental pain thresholds (r=-0.52, P<.001). In addition, chronic pain patients exhibited significantly elevated PSQ scores as compared to healthy controls, consistent with the generalized increase of experimentally determined pain perception that has repeatedly been reported in chronic pain patients. These results demonstrate that the PSQ constitutes a valid self-rating measure of pain perception outside the clinical pain site in chronic pain patients and might serve as an alternative to experimental assessment of pain perception outside the clinical pain site in situations where experimental pain testing is not feasible.
最近，一种基于想象中的日常疼痛情况的自评疼痛感知量表（PSQ）已经开发出来，并在健康受试者中显示出与实验获得的疼痛强度评分相关。在这里，我们评估了 PSQ 用于研究慢性疼痛患者一般疼痛感知（即临床疼痛部位以外的疼痛感知）的有效性。在 134 名慢性疼痛患者中获得了 PSQ 评分，并将其与 185 名健康对照组进行了比较。在 46 名慢性疼痛患者的亚组中，我们在临床疼痛部位之外进行了实验性疼痛测试，包括不同的方式（热、冷、压和刺痛）和不同的测量方法（疼痛阈值、疼痛强度评分）。结果表明，PSQ 评分与实验性疼痛强度评分（Pearson's r=0.71，P<.001）和实验性疼痛阈值（r=-0.52，P<.001）显著相关。此外，与健康对照组相比，慢性疼痛患者的 PSQ 评分显著升高，这与慢性疼痛患者中反复报道的实验性确定的疼痛感知普遍增加一致。这些结果表明，PSQ 构成了慢性疼痛患者临床疼痛部位以外的疼痛感知的有效自评测量方法，并且可能在实验性疼痛测试不可行的情况下，作为临床疼痛部位以外的疼痛感知的替代评估方法。
