海洋蓝细菌中的生物活性次生代谢产物。
Biologically active secondary metabolites from marine cyanobacteria.
机构信息
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Curr Opin Biotechnol. 2010 Dec;21(6):787-93. doi: 10.1016/j.copbio.2010.09.019. Epub 2010 Oct 26.
Abstract
Marine cyanobacteria are a rich source of complex bioactive secondary metabolites which derive from mixed biosynthetic pathways. Recently, several marine cyanobacterial natural products have garnered much attention due to their intriguing structures and exciting anti-proliferative or cancer cell toxic activities. Several other recently discovered secondary metabolites exhibit insightful neurotoxic activities whereas others are showing pronounced anti-inflammatory activity. A number of anti-infective compounds displaying activity against neglected diseases have also been identified, which include viridamides A and B, gallinamide A, dragonamide E, and the almiramides.
摘要
海洋蓝藻是复杂生物活性次生代谢产物的丰富来源，这些次生代谢产物源自混合生物合成途径。最近，由于其引人入胜的结构和令人兴奋的抗增殖或癌细胞毒性活性，几种海洋蓝藻天然产物引起了广泛关注。其他一些最近发现的次生代谢产物具有洞察力的神经毒性活性，而另一些则表现出明显的抗炎活性。还发现了许多具有抗传染病活性的化合物，可用于治疗被忽视的疾病，其中包括绿蝇胺 A 和 B、海人草酸 A、龙酰胺 E 和阿米尔酰胺。
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