Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2013;27(6):563-7. doi: 10.1080/14786419.2012.682992. Epub 2012 May 1.
A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark of Calophyllum thorelii. Their structures were established on the basis of spectroscopic methods, mainly one- and two-dimensional NMR. Antioxidant activity of the isolated compounds was tested using DPPH free radical scavenging assay and some exhibited remarkable effects with IC₅₀ of 13.63-17.46 µg mL(-1).
从藤黄科植物厚叶藤（Calophyllum thorelii）树皮的石油醚提取物中分离得到一个新的黄烷酮，即 calothorexanthone，以及五个已知化合物，即 garbogiol、1,4,8-三羟基黄烷酮、δ-生育三烯醇、1,7-二羟基黄烷酮和 globuxanthone。它们的结构是基于光谱方法，主要是一维和二维 NMR 确定的。采用 DPPH 自由基清除试验测定了分离化合物的抗氧化活性，其中一些化合物表现出显著的效果，IC₅₀为 13.63-17.46 µg mL(-1)。
