Stein M, Davis P, Emmanuel J, West G
Department of Clinical Pharmacology, University of Zimbabwe, Harare.
J Rheumatol. 1990 Oct;17(10):1337-9.
Spondyloarthropathies are rare in Africa and there is little data regarding HLA association. We prospectively studied 19 patients with spondyloarthropathy, recording clinical details and performing tissue typing (ABC loci). There were 9 patients with ankylosing spondylitis (8 males), all had severe spinal disease but none had ocular or cardiac involvement and HLA-B27 antigen was not found in any of the 7 patients tested; only one patient possessed a B7 crossreacting antigen. The 10 patients with Reiter's syndrome (8 males) had typical clinical features but again the HLA-B27 tissue type was not found. B7-CREG antigen was found in 7 of the 10 patients with Reiter's syndrome.
脊柱关节病在非洲较为罕见，关于HLA关联的数据很少。我们对19例脊柱关节病患者进行了前瞻性研究，记录临床细节并进行组织分型（ABC位点）。有9例强直性脊柱炎患者（8名男性），均有严重的脊柱疾病，但无一例有眼部或心脏受累，在检测的7例患者中均未发现HLA - B27抗原；只有1例患者具有B7交叉反应抗原。10例赖特综合征患者（8名男性）具有典型的临床特征，但同样未发现HLA - B27组织类型。在10例赖特综合征患者中有7例发现了B7 - CREG抗原。
