School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada K1N 6N5.
Contemp Clin Trials. 2012 Jul;33(4):839-47. doi: 10.1016/j.cct.2012.04.004. Epub 2012 Apr 21.
The objective of the Healthy Eating Aerobic and Resistance Training in Youth (HEARTY) trial (ClinicalTrials.Gov # NCT00195858) was to examine the effects of resistance training, with and without aerobic training, on percent body fat in sedentary, post-pubertal overweight or obese adolescents aged 14-18 years. This paper describes the HEARTY study rationale, design and methods.
After a 4-week supervised low-intensity exercise run-in period, 304 overweight or obese adolescents with a body mass index≥85th percentile for age and sex were randomized to 4 groups for 22 weeks (5 months): diet+aerobic exercise, diet+resistance exercise, diet+combined aerobic and resistance exercise, or a diet only waiting-list control. All participants received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of -250 kcal.
The primary outcome is percent body fat measured by Magnetic Resonance Imaging. Secondary outcomes include changes in anthropometry, regional body composition, resting energy expenditure, cardiorespiratory fitness, musculoskeletal fitness, cardiometabolic risk markers, and psychological health.
To our knowledge, HEARTY is the largest clinical trial examining effects of aerobic training, resistance training, and combined aerobic and resistance training on changes in adiposity and cardiometabolic risk markers in overweight and obese adolescents. The findings will have important clinical implications regarding the role that resistance training should play in the management of adolescent obesity and its co-morbidities.
健康饮食有氧运动和抗阻训练在青少年中的研究（HEARTY 试验）（ClinicalTrials.Gov # NCT00195858）的目的是检验抗阻训练，结合或不结合有氧运动，对久坐、青春期后超重或肥胖青少年（14-18 岁）体脂百分比的影响。本文描述了 HEARTY 研究的原理、设计和方法。
在 4 周的监督性低强度运动预试验期后，将 304 名超重或肥胖青少年（BMI≥同年龄和性别 85 百分位）随机分为 4 组，进行 22 周（5 个月）的试验：饮食+有氧运动、饮食+抗阻运动、饮食+联合有氧和抗阻运动，或饮食+等待名单对照组。所有参与者都接受了饮食咨询，旨在促进健康饮食，每天最大能量亏空为 -250 千卡。
主要结局是通过磁共振成像测量的体脂百分比。次要结局包括身体成分、身体成分分布、静息能量消耗、心肺功能、肌肉骨骼健康、心血管代谢风险标志物和心理健康的变化。
据我们所知，HEARTY 是迄今为止最大的临床试验，检验了有氧运动、抗阻训练和联合有氧和抗阻训练对超重和肥胖青少年体脂百分比和心血管代谢风险标志物变化的影响。研究结果将对抗阻训练在青少年肥胖及其合并症的管理中应发挥的作用具有重要的临床意义。
