有氧运动和抗阻训练对肥胖青少年腹部脂肪、载脂蛋白及高敏C反应蛋白的影响：HEARTY随机临床试验

Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial.

作者信息

Alberga A S, Prud'homme D, Kenny G P, Goldfield G S, Hadjiyannakis S, Gougeon R, Phillips P, Malcolm J, Wells G, Doucette S, Ma J, Sigal R J

机构信息

School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Werklund School of Education, University of Calgary, Calgary, Alberta, Canada.

出版信息

Int J Obes (Lond). 2015 Oct;39(10):1494-500. doi: 10.1038/ijo.2015.133. Epub 2015 Jul 23.

DOI:10.1038/ijo.2015.133

PMID:26202452

Abstract

OBJECTIVES

To investigate the effects of aerobic training, resistance training, or both on abdominal subcutaneous fat (subcutaneous adipose tissue (SAT)) (deep and superficial), visceral fat (visceral adipose tissue (VAT)), apolipoproteins A-1 and B (ApoA-1, ApoB), ApoB/ApoA-1 ratio and high-sensitivity C-reactive protein (HSCRP) in post-pubertal adolescents with obesity.

PARTICIPANTS

After a 4-week supervised moderate-intensity exercise run-in period, 304 postpubertal adolescents with overweight (body mass index (BMI) ⩾85th percentile for age and sex+diabetes risk factor) or obesity (⩾95th BMI percentile) aged 14-18 years were randomized to four groups for 22 weeks (5 months): aerobic training, resistance training, combined training or a non-exercising control.

METHODS

This study used a randomized controlled design. All groups received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of 250 kcal. Abdominal fat (SAT and VAT) at the level of the fourth and fifth lumbar vertebrae (L4-L5) was measured by magnetic resonance imaging and ApoA-1, ApoB and HSCRP were measured after a 12-h fast at baseline and after 6 months.

RESULTS

Changes in SAT at L4-L5 were -16.2 cm(2) in aerobic (P=0.04 vs control), -22.7 cm(2) in resistance (P=0.009 vs control) and -18.7 cm(2) in combined (P=0.02 vs control). Combined training reduced ApoB levels from 0.81±0.02 to 0.78±0.02 g l(-1) (P=0.04 vs control) and ApoB/ApoA-1 ratio from 0.67±0.02 to 0.64±0.02 (P=0.02 vs control and P=0.04 vs aerobic). There were no significant differences in VAT, ApoA-1 or HSCRP levels between groups.

CONCLUSIONS

Aerobic and resistance training and their combination decreased abdominal SAT in adolescents with obesity. Combined training caused greater improvements in ApoB/ApoA-1 ratio compared with aerobic training alone.

摘要

目的

探讨有氧运动训练、抗阻训练或两者联合训练对青春期后肥胖青少年腹部皮下脂肪（皮下脂肪组织（SAT），包括深层和浅层）、内脏脂肪（内脏脂肪组织（VAT））、载脂蛋白A - 1和B（ApoA - 1、ApoB）、ApoB/ApoA - 1比值及高敏C反应蛋白（HSCRP）的影响。

参与者

在为期4周的有监督的中等强度运动适应期后，304名14 - 18岁青春期后超重（体重指数（BMI）≥年龄和性别的第85百分位数+糖尿病风险因素）或肥胖（BMI≥第95百分位数）的青少年被随机分为四组，进行为期22周（5个月）的干预：有氧运动训练组、抗阻训练组、联合训练组或非运动对照组。

方法

本研究采用随机对照设计。所有组均接受旨在促进健康饮食的饮食咨询，每日最大能量 deficit 为250千卡。通过磁共振成像测量第四和第五腰椎（L4 - L5）水平的腹部脂肪（SAT和VAT），并在基线和6个月后禁食12小时后测量ApoA - 1、ApoB和HSCRP。

结果

L4 - L5水平SAT的变化在有氧运动训练组为 - 16.2平方厘米（与对照组相比，P = 0.04），抗阻训练组为 - 22.7平方厘米（与对照组相比，P = 0.009），联合训练组为 - 18.7平方厘米（与对照组相比，P = 0.02）。联合训练使ApoB水平从0.81±0.02降至0.78±0.02克/升（与对照组相比，P = 0.04），ApoB/ApoA - 1比值从0.67±0.02降至0.64±0.02（与对照组相比，P = 0.02；与有氧运动训练组相比，P = 0.04）。各组间VAT、ApoA - 1或HSCRP水平无显著差异。