Kato I, Kuroishi T, Tominaga S
Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya.
Jpn J Clin Oncol. 1990 Sep;20(3):232-7.
Recent time trends (1979-1987) and geographical distributions in mortalities from subsites of cancers of the hepato-biliary-pancreatic system have been investigated on the basis of the vital statistics of Japan. The corrected age-adjusted mortality rates (CAAMRs) were calculated to eliminate the influence of the proportion of subsite-unknown cancers. During the above period, the CAAMR for intrahepatic bile duct cancer increased by a relatively high extent (2.0-fold in males and 1.67-fold in females), and those for cancers of the gallbladder, extrahepatic bile duct and pancreas (head and other parts) increased to a moderate extent (1.2-1.4-fold). The CAAMR for primary liver cancer showed an increasing trend in males and a decreasing trend in females. The CAAMR for cancer of the ampulla Vater changed little during the period. A clear cluster of prefectures with high CAAMRs was observed in the northern part of Japan for cancers of the extrahepatic bile duct and pancreatic head. Clusters of prefectures with high CAAMRs for cancer of the gallbladder and ampulla Vater were observed in the mid-northern part of Japan, especially on the Japan Sea side. The CAAMR for primary liver cancer was high in the Island of Kyushu and some western parts of Japan, and low in the northern part of Honshu Island. No clear clusters of prefectures with high CAAMRs were observed for cancers of the intrahepatic bile duct and pancreas, other than for the pancreatic head.
基于日本的生命统计数据，对肝胆胰系统癌症各亚部位死亡率的近期时间趋势（1979 - 1987年）和地理分布进行了调查。计算了校正年龄调整死亡率（CAAMRs），以消除亚部位不明癌症比例的影响。在上述期间，肝内胆管癌的CAAMR上升幅度相对较高（男性为2.0倍，女性为1.67倍），胆囊癌、肝外胆管癌和胰腺癌（胰头及其他部位）的CAAMR上升幅度适中（1.2 - 1.4倍）。原发性肝癌的CAAMR在男性中呈上升趋势，在女性中呈下降趋势。壶腹癌的CAAMR在此期间变化不大。在日本北部观察到肝外胆管癌和胰头癌的CAAMR高的县明显聚集。在日本中北部，特别是在日本海一侧，观察到胆囊癌和壶腹癌的CAAMR高的县聚集。原发性肝癌的CAAMR在九州岛和日本西部部分地区较高，在本州岛北部较低。除胰头癌外，未观察到肝内胆管癌和胰腺癌的CAAMR高的县有明显聚集。
