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painters 职业性接触性皮炎:丹麦接触性皮炎研究组斑贴试验数据分析

Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group.

机构信息

Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Hellerup, Denmark.

出版信息

Contact Dermatitis. 2012 Nov;67(5):293-7. doi: 10.1111/j.1600-0536.2012.02074.x. Epub 2012 May 3.

Abstract

BACKGROUND

Painters are among the occupational groups that most commonly experience occupational contact dermatitis, but few investigations exist concerning this occupation.

OBJECTIVES

To characterize painters with contact dermatitis and identify the most common allergens associated with the occupation. Materials and methods. All patch test results of 219 painters and 1095 matched controls registered by the Danish Contact Dermatitis Group between 2001 and 2010 were analysed.

RESULTS

Hand eczema (p < 0.0001) and occupational contact dermatitis (p < 0.0001) were observed significantly more often in the painters than in the group of controls. Sensitizations to the following allergens from the European baseline series were associated with the occupation and were statistically significant: methylchloroisothiazolinone/methylisothiazolinone, epoxy resin, formaldehyde, and quaternium-15. Three different isothiazolinones emerged as the most frequent sensitizers of the allergens tested in addition to the baseline series.

CONCLUSIONS

The results indicate that painters have an increased risk of developing occupational hand eczema. Isothiazolinones and epoxy resin proved to be the two most frequent sensitizers in painters.

摘要

背景

油漆工是职业性接触性皮炎最常见的职业群体之一,但针对这一职业的研究较少。

目的

对接触性皮炎油漆工的特征进行描述,并确定与该职业相关的最常见的变应原。

材料和方法。分析了丹麦接触性皮炎组于 2001 年至 2010 年间登记的 219 名油漆工和 1095 名匹配对照者的所有斑贴试验结果。

结果

与对照组相比,油漆工中手部湿疹(p<0.0001)和职业性接触性皮炎(p<0.0001)的发生率明显更高。与职业相关且具有统计学意义的欧洲基本系列变应原致敏情况如下:甲基氯异噻唑啉酮/甲基异噻唑啉酮、环氧树脂、甲醛和季铵盐-15。除了基本系列外,还有三种不同的异噻唑啉酮成为测试变应原中最常见的致敏原。

结论

结果表明,油漆工发生职业性手部湿疹的风险增加。异噻唑啉酮和环氧树脂被证明是油漆工中最常见的两种致敏原。

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