Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
IEEE Trans Med Imaging. 2012 May;31(5):1076-85. doi: 10.1109/TMI.2012.2185247.
Projection magnetic particle imaging (MPI) can improve imaging speed by over 100-fold over traditional 3-D MPI. In this work, we derive the 2-D x-space signal equation, 2-D image equation, and introduce the concept of signal fading and resolution loss for a projection MPI imager. We then describe the design and construction of an x-space projection MPI scanner with a field gradient of 2.35 T/m across a 10 cm magnet free bore. The system has an expected resolution of 3.5 × 8.0 mm using Resovist tracer, and an experimental resolution of 3.8 × 8.4 mm resolution. The system images 2.5 cm × 5.0 cm partial field-of views (FOVs) at 10 frames/s, and acquires a full field-of-view of 10 cm × 5.0 cm in 4 s. We conclude by imaging a resolution phantom, a complex "Cal" phantom, mice injected with Resovist tracer, and experimentally confirm the theoretically predicted x-space spatial resolution.
投影式磁粒子成像（MPI）可以将传统的 3D-MPI 的成像速度提高 100 倍以上。在这项工作中，我们推导出了 2D-x 空间信号方程和 2D 图像方程，并引入了投影 MPI 成像仪的信号衰减和分辨率损失的概念。然后，我们描述了一种 x 空间投影 MPI 扫描仪的设计和构建，该扫描仪在 10cm 的无磁体孔径内具有 2.35T/m 的磁场梯度。该系统使用 Resovist 示踪剂的预期分辨率为 3.5×8.0mm，实验分辨率为 3.8×8.4mm。该系统以 10 帧/秒的速度对 2.5cm×5.0cm 的部分视场（FOV）进行成像，4 秒内采集 10cm×5.0cm 的全视场。最后，我们对分辨率体模、复杂的“Cal”体模、注射了 Resovist 示踪剂的小鼠进行成像，并通过实验验证了 x 空间空间分辨率的理论预测。
