Dieckhoff J, Kaul M G, Mummert T, Jung C, Salamon J, Adam G, Knopp T, Ludwig F, Balceris C, Ittrich H
Department for Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Phys Med Biol. 2017 May 7;62(9):3470-3482. doi: 10.1088/1361-6560/aa562d. Epub 2016 Dec 30.
Magnetic particle imaging (MPI) facilitates the rapid determination of 3D in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique. For instance, similar results were obtained between ferucarbotran embedded in freeze-dried mannitol sugar and liver tissue harvested after a ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data enlarged the field of view and increased the covering of liver MPI on magnetic resonance images noticeably.
磁粒子成像（MPI）有助于快速测定体内三维磁性纳米颗粒分布。在这项工作中，研究了静脉注射 ferucarbotran（Resovist）后的肝脏 MPI。图像重建基于校准测量，即所谓的系统函数。应用反映 ferucarbotran 颗粒迁移率和聚集状态的增强系统函数样本可显著改善图像重建。磁弛豫测量法和磁性粒子光谱技术对不同 ferucarbotran 成分的表征支持了这一发现。例如，冻干甘露醇糖中嵌入的 ferucarbotran 与注射 ferucarbotran 后采集的肝脏组织之间获得了相似的结果。此外，用于 MPI 数据联合重建的多个移位测量补丁的组合扩大了视野，并显著增加了磁共振图像上肝脏 MPI 的覆盖范围。
