Ferguson R Matthew, Minard Kevin R, Krishnan Kannan M
Materials Science and Engineering Department, University of Washington, Box 352120, Seattle, WA 98195-2120, USA.
J Magn Magn Mater. 2009;321(10):1548-1551. doi: 10.1016/j.jmmm.2009.02.083.
Magnetic particle imaging (MPI) is a powerful new research and diagnostic imaging platform that is designed to image the amount and location of superparamagnetic nanoparticles in biological tissue. Here, we present mathematical modeling results that show how MPI sensitivity and spatial resolution both depend on the size of the nanoparticle core and its other physical properties, and how imaging performance can be effectively optimized through rational core design. Modeling is performed using the properties of magnetite cores, since these are readily produced with a controllable size that facilitates quantitative imaging. Results show that very low detection thresholds (of a few nanograms Fe(3)O(4)) and sub-millimeter spatial resolution are possible with MPI.
磁粒子成像（MPI）是一个强大的新型研究和诊断成像平台，旨在对生物组织中超顺磁性纳米颗粒的数量和位置进行成像。在此，我们展示了数学建模结果，这些结果表明MPI的灵敏度和空间分辨率如何既取决于纳米颗粒核心的大小及其其他物理特性，以及如何通过合理的核心设计有效地优化成像性能。使用磁铁矿核心的特性进行建模，因为这些核心易于生产出可控的尺寸，便于进行定量成像。结果表明，MPI能够实现非常低的检测阈值（几纳克Fe(3)O(4)）和亚毫米级的空间分辨率。
