Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
IEEE Trans Med Imaging. 2011 Sep;30(9):1581-90. doi: 10.1109/TMI.2011.2125982. Epub 2011 Mar 10.
Magnetic particle imaging (MPI) is a promising new medical imaging tracer modality with potential applications in human angiography, cancer imaging, in vivo cell tracking, and inflammation imaging. Here we demonstrate both theoretically and experimentally that multidimensional MPI is a linear shift-invariant imaging system with an analytic point spread function. We also introduce a fast image reconstruction method that obtains the intrinsic MPI image with high signal-to-noise ratio via a simple gridding operation in x-space. We also demonstrate a method to reconstruct large field-of-view (FOV) images using partial FOV scanning, despite the loss of first harmonic image information due to direct feedthrough contamination. We conclude with the first experimental test of multidimensional x-space MPI.
磁性粒子成像（MPI）是一种很有前途的新型医学成像示踪剂模态，具有在人体血管造影、癌症成像、体内细胞跟踪和炎症成像方面的潜在应用。在这里，我们从理论和实验两方面证明多维 MPI 是一种具有解析点扩散函数的线性平移不变成像系统。我们还引入了一种快速图像重建方法，该方法通过在 x 空间进行简单的网格化操作，以高信噪比获得固有 MPI 图像。我们还展示了一种使用部分视野（FOV）扫描重建大 FOV 图像的方法，尽管由于直接馈通污染导致第一谐频图像信息丢失。最后，我们进行了多维 x 空间 MPI 的首次实验测试。
