人巨细胞病毒基因组特定区域在体外传代过程中的修饰
Modification of specific regions of the human cytomegalovirus genome during in vitro passage.
作者信息
Hamelin C, Dion M
机构信息
Centre de recherche en virologie, Institut Armand-Frappier, Laval-des-Rapides, Quebec.
出版信息
Can J Infect Dis. 1990 Summer;1(2):48-50. doi: 10.1155/1990/185934.
Abstract
Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus genome during in vitro passage.
摘要
使用克隆的Hind III片段对人巨细胞病毒AD - 169株DNA分子的不同区域进行稳定性测试。结果表明，在体外传代过程中，人巨细胞病毒基因组的所有部分核苷酸序列的插入、缺失和/或重排都以相对较高的频率发生。
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